Note: Several of these rules are based on my personal team loves and hates, so you can adapt them to fit your team preferences. I will attempt to not judge you for you these preferences. Also, my bracket has never won, but I did come in third last year.
1. If remotely feasibly possible, always pick UK to win it all. (Yes, it is very feasible this year.)
2. Try to find a feasible, quick exit for Duke, Tennessee and Louisville, because they're evil.
3. If your husband is a Louisville fan, pick them to win at least one game (if plausible) as a kindness to him.
4. Pick the local under dog for at least one game. In my case, this is normally Western Kentucky, Murray State or Morehead State.
Unfortunately, rules 3 and 4 are going head-to-head in the first round this year. I'm think I'm going to have to pick Morehead. ;)